Helena Bonham Carter and Tim Burton have split.
The couple, who have two children, Billy, 11, and Nell, seven, have announced they "separated amicably earlier this year" after 13 years together.
A spokesperson for the 48-year-old actress told PEOPLE.com: "[Helena and Tim] separated amicably earlier this year and have continued to be friends and co-parent their children. We would ask that you respect their privacy and that of their children during this time."
The duo started dating after Tim, 56, directed Helena in 'Planet of the Apes' in 2001 and had a famously unconventional relationship, living in two neighbouring houses joined by a communal room.
News of their split comes more than a year after Tim was photographed canoodling with another woman after a cinema date in Hampstead, London in September 2013.
But Helena rubbished allegations he had been unfaithful at the time, saying: "This is absolute nonsense. The pictures were taken whilst they were out and the large group includes family, friends and work colleagues."
Although they frequently worked together, Tim previously admitted they often had a turbulent relationship on set, especially during the making of 'Sweeney Todd: The Demon Barber of Fleet Street' in 2007.
He said: "We've survived [as a couple], but it hasn't always been easy. 'Sweeney Todd' was the worst; definitely the worst. But then I found out she was pregnant with Nell and it kind of all made sense."
Helena's friends think Tim "is having a classic mid-life crisis." The actress is reportedly devastated that her efforts to save their 13-year relationship have failed.
A source close to the 'Harry Potter' star said: "Tim is having a classic mid-life crisis. Hers friends think he's a terrible old cliche. Helena gave him a lot of time to sort himself out."
Another pal admitted to MailOnline that the actress isn't taking the split well, saying: "Helena was very upset at the Chequers party earlier this month hosted by Samantha Cameron. Other guests noticed she was in a bad way. She is really upset. It's all still very raw and they only told the children two weeks ago."
Photos 1 to 3 show the couple, while the rest show actor Johnny Depp, whom the director frequently works with.